Paul  J  Cheng-Hathaway

Entering Class: 2013
PhD Program: Neurosciences
Advisor: Gary Landreth, PhD & Bruce Lamb, PhD

Undergraduate Institution: University of California, Berkeley
Hometown: Union City, CA.

Research Interests: I am currently exploring how mutations in the triggering receptor expressed on myeloid cells-2 (TREM2) mediate myeloid cell (microglia/macrophages) function in the development of neurodegenerative disease.

About me: I am a California East Bay native. After graduating from UC Berkeley in 2010, I took several years off doing research at UC Berkeley and NINDS/NIH in Bethesda, MD. Outside of all things research and medicine, my interests include LGBT and minority affairs through QGrad (, SNMA/LMSA (, P.E.O.P.L.E. in Medicine/AMSA Gender & Sexuality (LGBTQ @ CWRUSOM, and exploring Cleveland's great food, music, and cultural scenes. Please contact us if you have questions about community/diversity here at CWRU and in the greater Cleveland area.

Comment about the MSTP program: CWRU MSTP is one of the top programs in the nation with a wealth of support for their students. If you are interested in applying or are currently doing so, please feel free to contact any of us with questions.

Featured Publication:

Jay TR, Bemiller S, Neilson LE, Cheng PJ, Lamb BT. Chapter 6: Neuroinflammation and Neurodegenerative Diseases in Neurodegenerative Diseases: Unifying Principles. Cummings JL, Pillai J (Ed). Oxford, NY: Oxford University Press. 2016. NLM ID: 101669322

Additional Publications:

Carol T. Burds, Paul J. Cheng, Susan Wray. Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation. PLOS One. June 25, 2015. DOI:10.1371/journal.pone.0131076

Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. Journal of Experimental Medicine. Mar 9, 2015. DOI: 10.1084/jem.20142322. PubMed Central PMCID: PMC4354365

L. Damla Kotan, B. Ian Hutchins, Yusuf Ozkan, Fatma Demirel, Hudson Stoner, Paul J. Cheng, Ihsan Esen, Fatih Gurbuz, Y. Kenan Bicakci, Eda Mengen, Bilgin Yuksel, Susan Wray, A. Kemal Topaloglu. Mutations in FEZF1 Cause Kallmann Syndrome. The American Journal of Human Genetics. September 4, 2014. DOI:

Guy Bar-Klein, Luisa P. Cacheux, Lyn Kamintsky, Ofer Prager, Itai Weissberg, Karl Schoknecht, Paul Cheng, Soo Young Kim, Lydia Wood, Uwe Heinemann, Daniela Kaufer, Alon Friedman. Losartan prevents acquired epilepsy via TGF-β signaling suppression. Annals of Neurology. March 19, 2014. DOI: 10.1002/ana.24147

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