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Email: smc143@case.edu

 

Steven  M  Chirieleison

Entering Class: 2012
PhD Program: Pathology
Advisor: Derek Abbott, MD, PhD
Laboratory: WRB 6404

Undergraduate Institution: University of Pennsylvania B.S.; The University of Texas at Austin M.S.
Hometown: Pittsburgh, PA.

Research Interests: I am interested in a variety of biomedical research areas. Currently, my main area of interest is in cell signaling and immunity.

About me: I enjoy spending my time outdoors with my wife, Rebecca, and our dog, Addie, when I can get away from school and lab.

Comment about the MSTP program: Case Western's MSTP has been everything I hoped and more. The students are actively engaged in the learning process, the faculty are enthusiastic, and the medical school provides world class training.

Featured Publication:

Chirieleison SM, Marsh RA, Kumar P, Rathkey JK, Dubyak GR, Abbott DW. Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-lined inhibitor of apoptosis (XIAP)-driven inflammatory disease. Journal of Biological Chemistry. 2017 Apr 12. pii: jbc.M117.781500. doi: 10.1074/jbc.M117.781500.

Additional Publications:

Chirieleison SM, Marsh RA, Kumar P, Rathkey JK, Dubyak GR, Abbott DW. Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-lined inhibitor of apoptosis (XIAP)-driven inflammatory disease. Journal of Biological Chemistry. 2017 Apr 12. pii: jbc.M117.781500. doi: 10.1074/jbc.M117.781500.

Dorand RD, Nthale J, Myers JT, Barkauskas DB, Avril S, Chirieleison SM, Pareek TK, Abbott DW, Stearns DS, Letterio JJ, Huang AY, Petrosiute A. Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity. Science, 22 Jul 2016: Vol. 353, Issue 6297, pp. 399-403. doi: 10.1126/science.aae0477

Chirieleison SM, Kertesy SB, Abbott DW. Synthetic Biology Reveals the Uniqueness of the RIP Kinase Domain. Journal of Immunology. 2016 May 15;196(10):4291-7. DOI: 10.4049/jimmunol.1502631

Perez JM, Chirieleison SM, Abbott DW. An IkappaB Kinase-Regulated Feedforward Circuit Prolongs Inflammation. Cell Rep. 2015 Jul 28;12(4):537-44. doi: 10.1016/j.celrep.2015.06.050. Epub 2015 Jul 16. PubMed PMID: 26190110; PubMed Central PMCID: PMC4520735.

Enyeart PJ, Chirieleison SM, Dao MN, Perutka J, Quandt EM, Yao J, Whitt JT, Keatinge-Clay AT, Lambowitz AM, Ellington AD. Generalized bacterial genome editing using mobile group II introns and Cre-lox. Molecular Systems Biology 9 Article number: 685 doi:10.1038/msb.2013.41

Chirieleison SM, Allen PB, Simpson ZB, Ellington AD, Chen X. Pattern transformation with DNA circuits. Nature Chemistry (2013) doi:10.1038/nchem.1764

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