Tyler  E  Miller

Entering Class: 2010
PhD Program: Pathology/Cancer Biology
Advisor: Jeremy Rich, MD, and Paul Tesar, PhD

Undergraduate Institution: Ohio State University
Hometown: Ottoville, OH.

Research Interests: I'm using advanced screening technologies to understand how epigenetic modifying genes regulate the cell state of oligodendrocyte progenitor cells and glioblastoma stem cells

About me: My wife and I married in 2010 and moved to Cleveland to start the next stage of our lives. We love Cleveland, love to cook and love to travel. Since 2010, we've been to 10 countries and lots of cities. (P.S. The independent restaurant scene in Cleveland is as good in any city I've been in this world, per capita)

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Featured Publication:

Miller TE, Liau BB, Wallace LC, Morton AR, Xie Q, Dixit D, Factor DC, Kim LJY, Morrow JJ, Wu Q, Mack SC, Hubert CG, Gillespie SM, Flavahan WA, Hoffmann T, Thummalapalli R, Hemann MT, Paddison PJ, Horbinski CM, Zuber J, Scacheri PC, Bernstein BE, Tesar PJ, Rich JN. Transcription elongation factors represent in vivo cancer dependencies in glioblastoma. Nature. 2017 Jul 20;547(7663):355-359. doi: 10.1038/nature23000. Epub 2017 Jul 5. PubMed PMID: 28678782.

Additional Publications:

Wang X, Huang Z, Wu Q, Prager BC, Mack SC, Yang K, Kim LJY, Gimple RC, Shi Y, Lai S, Xie Q, Miller TE, Hubert CG, Song A, Dong Z, Zhou W, Fang X, Zhu Z, Mahadev V, Bao S, Rich JN. MYC-regulated Mevalonate Metabolism Maintains Brain Tumor Initiating Cells. Cancer Res. 2017 Jul 20. pii: canres.0114.2017. doi: 10.1158/0008-5472.CAN-17-0114. [Epub ahead of print] PubMed PMID: 28729418.

Wang X, Yang K, Xie Q, Wu Q, Mack SC, Shi Y, Kim LJY, Prager BC, Flavahan WA, Liu X, Singer M, Hubert CG, Miller TE, Zhou W, Huang Z, Fang X, Regev A, Suvā ML, Hwang TH, Locasale JW, Bao S, Rich JN. Purine synthesis promotes maintenance of brain tumor initiating cells in glioma. Nat Neurosci. 2017 May;20(5):661-673. doi: 10.1038/nn.4537. Epub 2017 Mar 27. PubMed PMID: 28346452.

Liau BB, Sievers C, Donohue LK, Gillespie SM, Flavahan WA, Miller TE, Venteicher AS, Hebert CH, Carey CD, Rodig SJ, Shareef SJ, Najm FJ, van Galen P, Wakimoto H, Cahill DP, Rich JN, Aster JC, Suvā ML, Patel AP, Bernstein BE. Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance. Cell Stem Cell. 2017 Feb 2;20(2):233-246.e7. doi: 10.1016/j.stem.2016.11.003. PubMed PMID: 27989769; PubMed Central PMCID: PMC5291795.

Miller TE, Wang J, Sukhdeo K, Horbinski C, Tesar PJ, Wechsler-Reya RJ, Rich JN. Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development. PLoS One. 2014 Dec 10;9(12):e114433. doi: 10.1371/journal.pone.0114433. eCollection 2014. PubMed PMID: 25493560; PubMed Central PMCID: PMC4262395.

Xie Q, Wu Q, Kim L, Miller TE, Liau BB, Mack SC, Yang K, Factor DC, Fang X, Huang Z, Zhou W, Alazem K, Wang X, Bernstein BE, Bao S, Rich JN. RBPJ maintains brain tumor-initiating cells through CDK9-mediated transcriptional elongation. J Clin Invest. 2016 Jul 1;126(7):2757-72. doi: 10.1172/JCI86114. Epub 2016 Jun 20. PubMed PMID: 27322055; PubMed Central PMCID: PMC4922685.

Mack SC, Hubert CG, Miller TE, Taylor MD, Rich JN. An epigenetic gateway to brain tumor cell identity. Nat Neurosci. 2016 Jan;19(1):10-9. doi: 10.1038/nn.4190. Review. PubMed PMID: 26713744.

Najm FJ, Madhavan M, Zaremba A, Shick E, Karl RT, Factor DC, Miller TE, Nevin ZS, Kantor C, Sargent A, Quick KL, Schlatzer DM, Tang H, Papoian R, Brimacombe KR, Shen M, Boxer MB, Jadhav A, Robinson AP, Podojil JR, Miller SD, Miller RH, Tesar PJ. Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo. Nature. 2015 Jun 11;522(7555):216-20. doi: 10.1038/nature14335. Epub 2015 Apr 20. PubMed PMID: 25896324; PubMed Central PMCID: PMC4528969.

Ferrarese R, Harsh GR 4th, Yadav AK, Bug E, Maticzka D, Reichardt W, Dombrowski SM, Miller TE, Masilamani AP, Dai F, Kim H, Hadler M, Scholtens DM, Yu IL, Beck J, Srinivasasainagendra V, Costa F, Baxan N, Pfeifer D, von Elverfeldt D, Backofen R, Weyerbrock A, Duarte CW, He X, Prinz M, Chandler JP, Vogel H, hakravarti A, Rich JN, Carro MS, Bredel M. Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression. J Clin Invest. 2014 Jul 1;124(7):2861-76. doi: 10.1172/JCI68836. Epub 2014 May 27. PubMed PMID: 24865424; PubMed Central PMCID: PMC4071411.

Sukhdeo K, Koch CE, Miller TE, Zhou H, Rivera M, Yan K, Cepko CL, Lathia JD, Rich JN. The Lgr5 transgene is expressed specifically in glycinergic amacrine cells in the mouse retina. Exp Eye Res. 2014 Feb;119:106-10. doi: 10.1016/j.exer.2013.11.003. Epub 2013 Nov 15. PMCID: PMC3986349

Schonberg DL, Lubelski D, Miller TE, Rich JN. Brain tumor stem cells: Molecular characteristics and their impact on therapy. Mol Aspects Med. 2013 Jul 4. pii: S0098-2997(13)00044-7. doi: 10.1016/j.mam.2013.06.004. [Epub ahead of print] PMCID: PMC3866208

Venere M, Miller TE, Rich JN. Mitotic control of cancer stem cells. Cancer Discov. 2013 Feb;3(2):141-4. PMCID: PMC3616319

Beach JR, Hussey GS, Miller TE, Chaudhury A, Patel P, Monslow J, Zheng Q, Keri RA, Reizes O, Bresnick AR, Howe PH, Egelhoff TT. Myosin II isoform switching mediates invasiveness after TGF-ß-induced epithelial-mesenchymal transition. Proc Natl Acad Sci U S A. 2011. 108(44):17991-6. PMCID: PMC3207690

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