Tyler  E  Miller

Entering Class: 2010
PhD Program: Pathology/Cancer Biology
Advisor: Jeremy Rich, MD, and Paul Tesar, PhD

Undergraduate Institution: Ohio State University
Hometown: Ottoville, OH.

Research Interests: I'm using advanced screening technologies to understand how epigenetic modifying genes regulate the cell state of oligodendrocyte progenitor cells and glioblastoma stem cells

About me: My wife and I married in 2010 and moved to Cleveland to start the next stage of our lives. We love Cleveland, love to cook and love to travel. Since 2010, we've been to 10 countries and lots of cities. (P.S. The independent restaurant scene in Cleveland is as good in any city I've been in this world, per capita)

Comment about the MSTP program:

Featured Publication:

Miller TE, Wang J, Sukhdeo K, Horbinski C, Tesar PJ, Wechsler-Reya RJ, Rich JN. Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development. PLoS One. 2014 Dec 10;9(12):e114433. doi: 10.1371/journal.pone.0114433. eCollection 2014. PubMed PMID: 25493560; PubMed Central PMCID: PMC4262395.

Additional Publications:

Xie Q, Wu Q, Kim L, Miller TE, Liau BB, Mack SC, Yang K, Factor DC, Fang X, Huang Z, Zhou W, Alazem K, Wang X, Bernstein BE, Bao S, Rich JN. RBPJ maintains brain tumor-initiating cells through CDK9-mediated transcriptional elongation. J Clin Invest. 2016 Jul 1;126(7):2757-72. doi: 10.1172/JCI86114. Epub 2016 Jun 20. PubMed PMID: 27322055; PubMed Central PMCID: PMC4922685.

Mack SC, Hubert CG, Miller TE, Taylor MD, Rich JN. An epigenetic gateway to brain tumor cell identity. Nat Neurosci. 2016 Jan;19(1):10-9. doi: 10.1038/nn.4190. Review. PubMed PMID: 26713744.

Najm FJ, Madhavan M, Zaremba A, Shick E, Karl RT, Factor DC, Miller TE, Nevin ZS, Kantor C, Sargent A, Quick KL, Schlatzer DM, Tang H, Papoian R, Brimacombe KR, Shen M, Boxer MB, Jadhav A, Robinson AP, Podojil JR, Miller SD, Miller RH, Tesar PJ. Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo. Nature. 2015 Jun 11;522(7555):216-20. doi: 10.1038/nature14335. Epub 2015 Apr 20. PubMed PMID: 25896324; PubMed Central PMCID: PMC4528969.

Ferrarese R, Harsh GR 4th, Yadav AK, Bug E, Maticzka D, Reichardt W, Dombrowski SM, Miller TE, Masilamani AP, Dai F, Kim H, Hadler M, Scholtens DM, Yu IL, Beck J, Srinivasasainagendra V, Costa F, Baxan N, Pfeifer D, von Elverfeldt D, Backofen R, Weyerbrock A, Duarte CW, He X, Prinz M, Chandler JP, Vogel H, hakravarti A, Rich JN, Carro MS, Bredel M. Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression. J Clin Invest. 2014 Jul 1;124(7):2861-76. doi: 10.1172/JCI68836. Epub 2014 May 27. PubMed PMID: 24865424; PubMed Central PMCID: PMC4071411.

Sukhdeo K, Koch CE, Miller TE, Zhou H, Rivera M, Yan K, Cepko CL, Lathia JD, Rich JN. The Lgr5 transgene is expressed specifically in glycinergic amacrine cells in the mouse retina. Exp Eye Res. 2014 Feb;119:106-10. doi: 10.1016/j.exer.2013.11.003. Epub 2013 Nov 15. PMCID: PMC3986349

Schonberg DL, Lubelski D, Miller TE, Rich JN. Brain tumor stem cells: Molecular characteristics and their impact on therapy. Mol Aspects Med. 2013 Jul 4. pii: S0098-2997(13)00044-7. doi: 10.1016/j.mam.2013.06.004. [Epub ahead of print] PMCID: PMC3866208

Venere M, Miller TE, Rich JN. Mitotic control of cancer stem cells. Cancer Discov. 2013 Feb;3(2):141-4. PMCID: PMC3616319

Beach JR, Hussey GS, Miller TE, Chaudhury A, Patel P, Monslow J, Zheng Q, Keri RA, Reizes O, Bresnick AR, Howe PH, Egelhoff TT. Myosin II isoform switching mediates invasiveness after TGF--induced epithelial-mesenchymal transition. Proc Natl Acad Sci U S A. 2011. 108(44):17991-6. PMCID: PMC3207690

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