Please click on a name to view a more detailed profile.
Derek Abbott
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Inflammatory diseases and innate immune signaling pathways |
Eben Alsberg
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Biomimetic tissue engineering; innovative biomaterials and drug delivery
vehicles for functional tissue regeneration and cancer therapy; control of
stem cell differentiation |
James M Anderson
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Biocompatibility of implants, human vascular grafts, immune responses to foreign materials, phagocytosis, inflammation |
Eric Arts
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HIV-1 drug resistance to nucleoside and chemokine analogs; HIV-1 evolution and emergence of drug resistance in Africa. |
Radhika Atit
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Embryonic skin development |
Robert A Bonomo
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Structure function studies of Class A beta-lactamases. Understanding enzymological factors that permit the successful evolution of beta-lactamases in the clinic. Development of immunological tools to study beta-lactamase expression in enteric bacilli. |
W Henry Boom
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CD4+ T cells,CD8+ T cells,gamma delta T cells,tuberculosis,cytokines,antigen processing,anti-microbial immunity,HIV-1,pulmonary host defense |
Walter Boron
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Physiology of ion-transport processes involved in the regulation of intracellular pH |
Susan Brady-Kalnay
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Receptor protein tyrosine phosphatases, cell adhesion, and signal transduction; PTPs in adherens junctions and desmosomes. |
Heather Broihier
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Fundamental biological mechanisms guiding the generation of functional neuronal classes |
Henri Brunengraber
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Metabolic regulation, ketone body metabolism, design and testing of synthetic nutrients, ethanol metabolism, lipogenesis |
Matthias Buck
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Molecular Biophysics of small GTPase-protein interactions in neuronal cell
signaling. We use molecular biology, NMR and X-ray spectroscopy as well as thermodynamic
measurements to determine the basic mechanisms by which proteins transmit signals
in cells. Principal project: The plexin transmembrane receptor in axon guidance. |
Arnold Caplan
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Developmental and cell biology and biochemistry of muscle, cartilage, bone, skin and connective tissue, with emphasis on how stem cells differentiate under conditions of tissue-engineered regeneration |
Paul Carey
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Enzyme mechanisms, Raman spectroscopy, beta-lactamases and ribozymes, physical biochemistry |
Mark Chance
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Protein Structure / Function: Digestive, Liver and Epithelial, Endocrine, Metabolic Disorders, Cancer, Diabetes |
Margaret Chandler
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Systems Integrated Physiology: Muscle, Heart, Metabolic Disorders, Hypertension, Diabetes, Cardiovascular Disease |
Shu G. Chen
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Aging; cell biology; dementia; degenerative disease; neuroscience; prion disease; protein chemistry |
Hillel Chiel
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Neural networks, electrophysiology, modeling, Aplysia, biomechanics, feeding behavior. |
Brian Cobb
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Antigen processing and presentation of carbohydrate antigens |
Colleen Croniger
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The molecular changes in the pancreas of animal models that are either resistant or sensitive to obesity in response to environmental stresses such as caffeine and a high-fat diet. |
Piet De Boer
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Bacterial molecular genetics; biochemistry and cell biology; formation of the division of septum and related cell cycle events |
Chris Dealwis
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Understanding the structural organization requirements by multiple protein assemblies to facilitate biological function |
Evan Deneris
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Mechanisms of neuronal gene expression, cholinergic and serotonergic transmitter systems. |
LR Devireddy
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Lipocalin 24p3 and its role in apoptosis, iron transport, innate immmunity, and myeloproliferative disease |
Clark Distelhorst
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Steroid hormone action; programmed cell death; apoptosis. |
J. Kevin Donahue
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Cardiac arrhythmia mechanisms, arrhythmia therapy outcomes, gene therapy, virology |
George Dubyak
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Signal transduction involving receptors for extracellular ATP; inflammatory signal transduction mechanisms; mechanisms of nucleotide release and extracellular metabolism. |
Jeffrey Duerk
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Magnetic resonance imaging, flow visualization, interventional MRI, rapid MR imaging, MR vessel wall imaging |
Dominique Durand
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Neural engineering, neural prostheses, magnetic and electric stimulation of the nervous system, electrophysiology of epilepsy, computational neuroscience. |
Thomas Egelhoff
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Signaling pathways and mechanics of cancer cell chemotaxis; cell biology of
chemotaxis in the model organism Dictyostelium discoideum. |
Robert Elston
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Development of statistical methods for analyzing family and pedigree data for the identification of genes that cause disease, implementing them in computer programs, and applying them in collaborative research with others who collect family data. |
Charis Eng
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Genomics-based personalized cancer risk assessment; Genetics and sub-cellular trafficking of PTEN in breast carcinogenesis |
Agata A Exner
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Minimally invasive methods of cancer treatment including: ultrasound-modulated, image-guided drug delivery, thermosensitizers for focused hyperthermia, and vasomodulation for improved local ablation and treatment follow-up |
Robert Fairchild
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T-lymphocyte tolerance, transplantation immunology |
Steven Fisher
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Regulation of gene expression and phenotypic switching in vascular smooth muscle; role of programmed cell death and
chamber-specific gene expression during heart development |
Thomas Gerken
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Protein structure and dynamics; NMR techniques; molecular modeling of glycoproteins and mucins |
Stanton Gerson
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Transgenic mice and carcinogenesis, retroviral gene therapy, DNA repair, hematopoietic stem cells |
Edward Greenfield
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Osteoporosis, loosening of orthopaedic implants, cytokines, osteoblasts, osteoclasts, bone resorption, cell-cell interactions, osteosarcoma, signal transduction |
Kenneth J Gustafson
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Neural engineering and neural prosthesis development with a focus on understanding systems-level neurophysiology and neural control of pelvic functions |
Thomas Hamilton
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Analysis of mechanisms regulating inflammatory gene expression in mononuclear phagocytes. Analysis of stimulus-dependent control of chemokine and cytokine mRNA stability. |
Clifford Harding
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Immunology, major histocompatibility complex (MHC) molecules, antigen processing, function of antigen presenting cells and T cells, Toll-like receptors, vaccine adjuvants, Cell Biology, phagocytosis, endocytosis, subcellular fractionation, Infectious Disease, mycobacteria, tuberculosis |
Michael Harris
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Molecular recognition and catalysis by the ribonuclease P: A ribonucleoprotein enzyme, and analysis of phosphoryl transfer mechanisms using kinetic isotope effects |
Peter Harte
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Epigenetic regulation of chromatin structure and transcription, histone modifying enzymes, Polycomb silencing, genetic control of lifespan and aging |
Nikki Harter
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Understanding the nature of cellular quiescence, the counterpart to proliferation; the role of MyoD in the biology of satellite cells, the adult stem cells of skeletal muscle; and the epigenetic specification of melanoma |
Maria Hatzoglou
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Arginine metabolism, gene regulation, viral receptors and gene therapy |
Stanley Hazen
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inflammation biology, free radicals and oxidation chemistry, internal medicine, endocrinology |
Stefan Herlitze
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Modulation of ion channels, signaling pathways and neuronal networks for mouse physiology and behavior |
Christopher Hernandez
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Mechanical Properties of Cancellous Bone and Bone Adaptation and Cancellous Bone Mechanics |
Amy Hise
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Innate immunology; Host defense to Candida albicans and oral microbes; Immune recognition of Rift Valley fever virus; Genetic polymorphisms and innate immunity |
Charles L. Hoppel
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The main focus of the laboratory is mitochondrial fatty acid oxidation. The organization of the pathway for mitochondrial fatty acid oxidation is of particular interest as a potential site for control of the system. |
Alex Huang
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Tumor Immunology; Intravital two-photon laser scanning microscopy; T cell and chemokine receptor biology; Cellular trafficking, migration and interaction in inflammation, cancer and auto-immunity |
Sudha Iyengar
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Genetics of complex diseases in humans |
Leila Jackson
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Lifestyle, environmental, and occupational factors and their impact on reproductive and perinatal health |
Mukesh Jain
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Transcriptional mechanisms governing cellular differentiation and function |
Eckhard Jankowsky
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Single molecule enzymology (RNA helicases) & single molecule studies of ribonucleoprotein machinery (HCV replication and pre-mRNA splicing) |
Hung-Ying Kao
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The ultimate goal of my research is to understand the mechanisms of the transcriptional control by diverse signaling pathways and the molecular basis of human diseases related to transcriptional regulation. One of the approaches toward these goals is using nuclear hormone receptors as a model system. Another major focus of my research is to characterize the biochemical properties and to determine the physiological role of the newly identified class II histone deacetylases. |
Jonathan Karn
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Control of Gene Expression in HIV |
David Katz
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Regulatory interactions in development of the nervous system, neurotransmitter phenotypes, neural growth factors. |
James Kazura
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Immunoregulatory mechanisms of pathogenesis; acquired resistance to infection; malaria |
Ruth Keri
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Hormonal control of mammary gland development and construction of transgenic mouse models of breast cancer; functional genomics of mammary gland development and cancer. |
Christopher L King
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T cell differentiation, Malaria Schistosomiasis, Filariasis Neonatal immunity, IgE regulation Mechanisms of acquired immunity |
Robert Kirsch
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Mechanics and control of human movement |
Joseph Lamanna
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Cerebral blood flow, cerebral ischemia, blood-brain barrier |
Bruce Lamb
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Alzheimer's Disease; Genomic Imprinting and Epigenetics; Yeast Artificial Chromosome Transgenic Mice; Models of Human Disease; Epigenetic Gene Regulation; Developmental Control of Epigenetics |
Lynn Landmesser
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Formation of neural circuits, growth cone guidance, synapse plasticity, activity dependant processes. |
Gary Landreth
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Nerve growth factor, protein kinases, MAP 2 kinase, Alzheimer's disease. |
Michael Lederman
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Mechanisms of immune deficiency and immune restoration in HIV infection |
Alan Levine
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Immune regulation, with targeted interest in (i) IBD in the intestine: Role of the mucosal T lymphocyte and epithelial cell, (ii) Intestinal permeability in HIV infection, and (iii) Link between chronic inflammation and colorectal cancer |
Xiaoxia Li
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Signal transduction in innate and adaptive immunity |
Hua Lou
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Alternative RNA processing and its role in cancer development |
Paul MacDonald
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Molecular mechanisms of vitamin D- and nuclear receptor-mediated gene expression. |
Mike Maguire
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Mg2+ homeostasis; Structure of Mg2+ channels, esp. the CorA superfamily of channels; Role of Mg2+ in Salmonella pathogenesis |
Danny Manor
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Etiology, treatment and prevention of cancer: signal transduction pathways that regulate normal cell growth; molecular prevention |
Roger Marchant
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Biomaterials. Biopolymers, bio-synthetic surfactants, polymer surface modification for implants and sensors, protein-surface interactions by AFM. |
Stephen Maricich
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My laboratory studies the development of the brainstem components of the central auditory system (cochlear nucleus, superior olivary complex and nuclei of the trapezoid body) with the ultimate goal of understanding where these structures arise, the developmental relationships of the cells in these structures, and how perturbations of one part of the system effect the development and function of other components. |
Sanford Markowitz
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Colon cancer genetics |
Cameron McIntyre
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Interaction between electric fields and the Nervous System, specifically Deep Brain Stimulation (DBS) |
Thomas M. McIntyre
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Human endothelial cell, monocyte/macrophage and leukocyte function. Inflammatory signaling molecules, lipid mediators and intercellular adhesion molecules. Enzymes that make and degrade Platelet-activating Factor, phospholipid oxidation and eicosanoid function. |
William Merrick
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Mechanism and regulation of eukaryotic protein biosynthesis |
Robert Miller
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Developmental neurobiology, glial function, CNS pattern formation |
Booki Min
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Homeostatic control of T cell subsets, CD4, CD8, and gamma delta T cells; Immunoregulatory roles of basophils in Th2 immunity |
Kathy Molyneaux
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Development of the mammalian gonad |
Vincent Monnier
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Molecular mechanisms of protein aging, oxidative stress, complications of diabetes and aging, cataractogenesis, microbial enzyme technology |
Joseph Nadeau
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Comparative Mapping and Mouse Models of Human Disease; Networks of Control of Gene Expression; Genetic and Phenotypic Dissection of Complex Traits Using Mouse Genomics |
Laura Nagy
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Innate immunity and liver disease, ethanol and signal transduction |
Liem Nguyen
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Host-mycobacterial interactions; virulence factors of Mycobacterium tuberculosis; antibiotic resistance and cell biology of mycobacteria |
Timothy Nilsen
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RNA processing and transcription in nematodes. Homologous cell free systems are used to dissect in detail the mechanisms of cis- and trans-splicing as well as the transcription of UsnRNA genes |
Noa Noy
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Mechanisms of action and biological functions of nuclear hormone receptors |
Krzysztof Palczewski
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Mapping the Visual Transduction System |
Paul Park
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Mechanism of action of rhodopsin and other G protein-coupled receptors |
Eric Pearlman
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The Pearlman laboratory is involved in two major projects on innate immunity: Innate immune responses in fungal infections of the eye, and Role of toll like receptors in bacterial keratitis |
P. Hunter Peckham
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Motor function restoration with neural prostheses, control of orthotic and prosthetic systems. |
Marc S Penn
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myocardial ischemia, vascular biology, cardiac critical care |
Richard Ransohoff
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multiple sclerosis, neuroimmunology |
Jeremy Rich
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Brain tumors display a hierarchy of tumor cells with a subset of the neoplastic compartment sharing characteristics with stem cells. We have shown that these cancer stem cells are resistant to radiotherapy and promote angiogenesis. Our current studies are directed towards better understanding cancer stem cell biology to develop new cancer therapies. |
Clare M Rimnac
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Mechanical performance of orthopaedic total joint replacements through fundamental materials studies and implant retrieval analysis; skeletal fragility of bone tissue (damage accumulation and repair); design and manufacture of resorbable polymeric scaffolds for bone tissue regeneration and repair. |
Andrew Rollins
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The application of advanced optics and photonics technologies for in vivo microscopic imaging and characterization of biological tissues, with particular emphasis on early cancer detection and phenotyping and morphometry in early cardiac development using Optical Coherence Tomography. |
David Rosenbaum
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Mechanisms of arrhythmias, cardiac repolarization, and intercellular coupling |
Robert G Salomon
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The role of lipid oxidation in disease, develop new diagnostic tools for identifying individuals at risk and assessing the efficacy of therapeutic interventions, provide a molecular basis for the design of new drugs and strategies |
Helen Salz
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Drosophila molecular genetics; Post-transcriptional control of cell fate determination; Alternative RNA splicing |
Steven Sanders
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The goal of our research is to understand the role of enzymes that mark chromatin by post-translational modification and how deregulation of these enzymes contributes to the development of cancer. |
Peter Scacheri
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Genomics of cancer and other human diseases with underlying defects in chromatin structure and function |
Ganes Sen
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Molecular Virology, Mechanism of Interferon Action, Recombinant DNA Technology, Genetic Regulation of Hypertension |
Jerry Silver
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Role of glial cells in development and regeneration of neural circuits, nerve regeneration, glia, axon guidance |
Roy Silverstein
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thrombosis, athersclerosis, angiogenesis |
Mark Smith
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Aging, Alzheimer disease, cell cycle control, cytoskeletal organization, neurodegeneration, oxidative stress |
Corey Smith
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Endocrine, Brain and Nervous System, Heart, Metabolic Disorders, Hypertension, Pulmonary Disease, Cardiovascular Disease |
Catherine Stein
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Genetic and environmental susceptibility to tuberculosis and other infectious diseases, and multivariate methods for analyzing complex diseases |
Benjamin Strowbridge
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Synaptic Physiology, hippocampus, olfactory bulb, Computational Neuroscience. |
Carlos Subauste
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Immunology, cell signaling in host-pathogen interactions, Toxoplasma, HIV, autophagy, selective blockade of CD40 signaling to control disorders such as atherosclerosis and microvascular complications of diabetes |
Keiko Tamai
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Understanding signaling pathways that determine early pattern formation of vertebrate embryogenesis, particularly the molecular mechanisms of the Wnt signaling pathway |
Ronald Triolo
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Rehabilitation engineering, neural control of motion, lower- extremity neuroprostheses, orthopaedic biomechanics and prosthetic/orthotic design |
Vincent Tuohy
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Autoimmunity, Multiple Sclerosis |
Saba Valadkhan
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Function of human snRNAs, functional analysis of large non-coding RNAs |
Focco van den Akker
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The overall goal of my research is to elucidate the molecular intricacies of enzyme mechanism and receptor activation. Our structural biology projects range from guanylyl cyclases (blood pressure, vision, and bone growth) to beta-lactamases (largely responsible for the current epidemic antibiotic resistance). |
Horst von Recum
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The research in our laboratory focuses on novel platforms for the delivery of molecules and cells. |
Zhenghe John Wang
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Identifying novel genetic alterations, such as somatic mutations, gene amplifications and deletions, which alter critical gene functions involved in development of colon and gastric cancers |
Bingcheng Wang
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Molecular mechanisms governing cell migration and proliferation, experimental therapy of cancer metastasis using tumor-targeting peptides. |
Michael Weiss
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Structural mechanisms of human diseases; Transcriptional deregulation and protein misfolding with applications to diabetes and disorders of sexual development |
David Wilson
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Biomedical image processing; digital processing and quantitative image quality of X-ray fluoroscopy images; interventional MRI. |
Xin Yu
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Cardiovascular physiology; magnetic resonance imaging and spectroscopy; characterization of the structure-function and energy–function relationships in normal and diseased hearts; small animal imaging and spectroscopy |
Michael Zagorski
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structures and mechanisms involved in protein mis-folding and amyloid formation. |
Qing Zheng
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Genes, molecular pathways and drug discovery involved in disease processes in mouse models of human deafness, including Otitis Media (OM) and Usher syndrome |
Xiongwei Zhu
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Neurodegenerative mechanisms underlying Alzheimer disease and other neurodegenerative diseases |
